Fetuin-Mineral Complex Reflects Extraosseous Calcification Stress in CKD
نویسندگان
چکیده
منابع مشابه
Fetuin-mineral complex reflects extraosseous calcification stress in CKD.
Fetuin-A is an important inhibitor of extraosseous calcification, but some of the studies that used ELISAs did not identify a significant relationship between serum fetuin-A levels and vascular calcification in patients with chronic kidney disease (CKD). Here, we used centrifugation to separate a fetuin-mineral complex (FMC) composed of fetuin-A, fibrinogen, fibronectin-1, and calcium from the ...
متن کاملFetuin-A protects against atherosclerotic calcification in CKD.
Reduced serum levels of the calcification inhibitor fetuin-A associate with increased cardiovascular mortality in dialysis patients. Fetuin-A-deficient mice display calcification of various tissues but notably not of the vasculature. This absence of vascular calcification may result from the protection of an intact endothelium, which becomes severely compromised in the setting of atherosclerosi...
متن کاملSerum levels of the fetuin-mineral complex correlate with artery calcification in the rat.
The present studies were carried out to evaluate the possible association between the presence of the fetuin-mineral complex in serum and vitamin D-induced artery calcification. The first experiment shows that there is a fetuin-mineral complex in the blood of rats in which extensive calcification of the artery media has been induced by treatment with vitamin D for 96 h, and that there is no det...
متن کاملFetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice.
BACKGROUND Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis. METHODS We studied the role of fetuin-A in CKD-associated calcification using a mouse model of graded renal insufficiency generated by nephrectomy and high phos...
متن کامل[Vascular calcification in CKD].
As doenças cardiovasculares (DCV) constituem a principal causa de mortalidade em pacientes com doença renal crônica (DRC).1 O risco de óbito por DCV nessa população chega a ser 10 a 30 vezes maior que aquele observado na população geral. Esse aumento da mortalidade também ocorre em pacientes nos estágios precoces da DRC,2 assim como naqueles submetidos a transplante renal.3 A alta prevalência d...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2010
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2009090944